Format

Send to

Choose Destination
Chembiochem. 2015 Mar 23;16(5):766-71. doi: 10.1002/cbic.201402650. Epub 2015 Feb 25.

A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.

Author information

1
Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main (Germany).

Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

KEYWORDS:

Photorhabdus; biosynthesis; entomopathogenic bacteria; juvenile hormone epoxide hydrolase inhibitor; natural products

PMID:
25711603
PMCID:
PMC4486325
DOI:
10.1002/cbic.201402650
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center