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Exp Biol Med (Maywood). 2015 Mar;240(3):351-60. doi: 10.1177/1535370214566558. Epub 2015 Feb 20.

Versatile communication strategies among tandem WW domain repeats.

Author information

1
Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
2
Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel oraf@ekmd.huji.ac.il.

Abstract

Interactions mediated by short linear motifs in proteins play major roles in regulation of cellular homeostasis since their transient nature allows for easy modulation. We are still far from a full understanding and appreciation of the complex regulation patterns that can be, and are, achieved by this type of interaction. The fact that many linear-motif-binding domains occur in tandem repeats in proteins indicates that their mutual communication is used extensively to obtain complex integration of information toward regulatory decisions. This review is an attempt to overview, and classify, different ways by which two and more tandem repeats cooperate in binding to their targets, in the well-characterized family of WW domains and their corresponding polyproline ligands.

KEYWORDS:

WW domain; WW domain containing oxidoreductase; Yes-associated protein; cooperative binding; peptide-mediated interactions; protein domain repeats; regulation of signaling

PMID:
25710931
PMCID:
PMC4436281
DOI:
10.1177/1535370214566558
[Indexed for MEDLINE]
Free PMC Article

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