Format

Send to

Choose Destination
Dev Cell. 2015 Feb 23;32(4):435-46. doi: 10.1016/j.devcel.2015.01.010.

It takes a village: constructing the neurogenic niche.

Author information

1
Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
2
SUNY Polytechnic Institute, College of Nanoscale Science and Engineering, Albany, NY 12203, USA.
3
Neural Stem Cell Institute, Rensselaer, NY 12144, USA. Electronic address: sallytemple@neuralsci.org.

Abstract

Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How does the niche change structurally and functionally during embryogenesis and in adulthood? In this review, we focus on the impact of non-neural cells that participate in the neurogenic niche, highlighting how cells of different embryonic origins influence this critical germinal space.

PMID:
25710530
PMCID:
PMC4886554
DOI:
10.1016/j.devcel.2015.01.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center