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J Ophthalmic Vis Res. 2014 Oct-Dec;9(4):417-22. doi: 10.4103/2008-322X.150803.

Topical cyclosporine a for treatment of dry eye due to chronic mustard gas injury.

Author information

1
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran ; Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
3
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
4
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
5
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.

Abstract

PURPOSE:

To evaluate the efficacy of topical cyclosporine A (tCsA) for treatment of dry eye disease in patients suffering from chronic ocular complications of mustard gas (MG) injury.

METHODS:

This interventional case series included patients with MG injury suffering from severe dry eye despite receiving artificial tears and punctal plugs. Patients were administered tCsA 0.05% twice daily for 3 months. Severity of the condition was evaluated by measuring tear osmolarity, ocular surface disease index (OSDI), tear break-up time (TBUT), and Schirmer's test at baseline and at the end of study.

RESULTS:

A total of 34 patients with chronic MG injury and mean age of 47.1 ± 6.5 years were studied. Compared to baseline values, tear osmolarity (301.7 ± 11.5 vs. 286.3 ± 7.9 mOsmol/L, P < 0.001) and OSDI (47.5 ± 7.2 vs. 42.7 ± 7.1, P < 0.001) were significantly improved. Likewise, Schirmer's test (4.6 ± 1.3 vs. 5 ± 1.3 mm, P < 0.001) and TBUT (1.9 ± 1.4 vs. 2.7 ± 1.5 s, P < 0.001) also significantly recovered at the end of the study.

CONCLUSION:

TCsA 0.05% reduces tear osmolarity and improves dry eye symptoms and can serve as an efficacious treatment for ocular complications in patients with chronic MG injury.

KEYWORDS:

Cyclosporine A; Dry Eye Syndrome; Mustard Gas; Tear Osmolarity

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