Format

Send to

Choose Destination
Trends Biotechnol. 2015 Apr;33(4):230-6. doi: 10.1016/j.tibtech.2015.01.004. Epub 2015 Feb 20.

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer.

Author information

1
Temple University, Bioengineering, 1947 North 12th Street, Engineering Building, Room 811, Philadelphia, PA 19122, USA; Fox Chase Cancer Center, Cancer Biology, Temple Health, 333 Cottman Ave, Philadelphia, PA 19111, USA.
2
Temple University, Bioengineering, 1947 North 12th Street, Engineering Building, Room 811, Philadelphia, PA 19122, USA. Electronic address: pilelkes@temple.edu.
3
Fox Chase Cancer Center, Cancer Biology, Temple Health, 333 Cottman Ave, Philadelphia, PA 19111, USA. Electronic address: edna.cukierman@fccc.edu.

Abstract

The extracellular matrix (ECM) provides structural and biochemical signals that regulate cell function. A well-controlled balance between cells and surroundings (i.e., dynamic reciprocity) is crucial for regulating ECM architecture. During cancer progression, epithelial cells undergo genetic alterations which, together with stromal changes including ECM remodeling, disturb the homeostatic dynamics of the epithelium. A parallel organization of stromal ECM fibrils is associated with tumorigenic responses. In an emerging paradigm, continuous and progressive regulation via mechanical forces and aberrant signaling are believed to be responsible for tumor-associated ECM remodeling. In this review we discuss the discrete biomechanical and biochemical mechanisms that underlie these architectural changes and highlight their particular relevance to the regulation of the alignment of ECM in the mesenchymal stroma.

KEYWORDS:

Rho–ROCK; biomechanical and biochemical cues; cell–ECM dynamic reciprocity; desmoplasia; extracellular matrix; integrins

PMID:
25708906
PMCID:
PMC4380578
DOI:
10.1016/j.tibtech.2015.01.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center