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Bull Exp Biol Med. 2015 Feb;158(4):461-4. doi: 10.1007/s10517-015-2785-0. Epub 2015 Feb 24.

Effects of immunomodulators on functional activity of innate immunity cells infected with Streptococcus pneumoniae.

Author information

1
G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia, pl_pat@hotmail.com.

Abstract

Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia. The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis. Analysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia.

PMID:
25708326
DOI:
10.1007/s10517-015-2785-0
[Indexed for MEDLINE]

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