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Gene. 1989 Jun 30;79(1):59-70.

Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex.

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1
Laboratoire de Génétique Physiologique, Institut de Biologie Moléculaire et Cellulaire du C.N.R.S., Strasbourg, France.

Abstract

The 6636 bp of the yeast URA2 gene encoding the carbamoylphosphate synthetase-aspartate transcarbamylase complex have been sequenced. The protein is organized into four regions, three of which are functional domains as indicated previously by genetic analysis. The fourth domain corresponds to a defective dihydroorotase called DHOase-like. The URA2 gene complex with the same organization as the equivalent genes in higher eukaryotes suggests an evolution from a common ancestral gene.

PMID:
2570735
[Indexed for MEDLINE]
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