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Org Lett. 2015 Mar 6;17(5):1110-3. doi: 10.1021/ol503610b. Epub 2015 Feb 23.

Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity.

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State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany and ∥Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.


Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-β1-induced human renal proximal tubular cells.

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