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Semin Cell Dev Biol. 2015 Apr;40:4-7. doi: 10.1016/j.semcdb.2015.02.005. Epub 2015 Feb 19.

EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research.

Author information

1
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
2
Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
3
Krefting Research Centre, Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 405 30, Sweden.
4
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea. Electronic address: ysgho@postech.ac.kr.

Abstract

For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-specific cargos are considered as novel diagnostic biomarkers as well as therapeutic targets. With the advancement in high-throughput technologies on multiomics studies and improvements in bioinformatics approaches, a huge number of vesicular proteins, mRNAs, miRNAs, lipids, and metabolites have been identified, and our understanding of these complex extracellular organelles has considerably increased during these past years. In this review, we highlight EVpedia (http://evpedia.info), a community web portal for systematic analyses of prokaryotic and eukaryotic extracellular vesicles research.

KEYWORDS:

Communicasomes; Ectosomes; Exosomes; Microvesicles; Nanocosmos; Outer membrane vesicles

PMID:
25704310
DOI:
10.1016/j.semcdb.2015.02.005
[Indexed for MEDLINE]

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