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Clin Neurophysiol. 2015 Nov;126(11):2058-67. doi: 10.1016/j.clinph.2015.01.010. Epub 2015 Jan 24.

Cognitive enhancement of healthy young adults with hyperbaric oxygen: A preliminary resting-state fMRI study.

Author information

1
Centre for Hyperbaric Oxygen and Neurorehabilitation, Liuhuaqiao Hospital, Guangzhou, China.
2
Centre for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
3
Centre for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China; Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, China.
4
Centre for Hyperbaric Oxygen and Neurorehabilitation, Liuhuaqiao Hospital, Guangzhou, China. Electronic address: xqy7180@163.com.
5
Centre for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China. Electronic address: ruiwang.huang@gmail.com.

Abstract

OBJECTIVE:

To date, no study has examined the effect of hyperbaric oxygen (HBO) on the cognitive performance and spontaneous brain activity in healthy adults using resting-state functional magnetic resonance imaging (rsfMRI). Our aim was to reveal the neural mechanism underlying the change in cognitive performance caused by increased oxygen.

METHODS:

In this study, we acquired fMRI data from 20 healthy young adults and used placebo-controlled (PBO) rsfMRI to identify the effect of HBO on the cognitive measures and the regional homogeneity (ReHo) in healthy adults.

RESULTS:

Compared to the PBO group, the HBO group showed the following: (1) the scores of the spatial working memory and memory quotient were significantly increased after HBO administration; (2) the ReHo value was significantly increased in three clusters, the left hippocampus, right inferior frontal, and lingual gyri, and for these three clusters, their functional connectivity with the subcortical brain system was significantly increased after HBO administration; and (3) the changes of ReHo values in these clusters generated by HBO administration were correlated with several aspects of cognitive performance, clarifying the cognitive locus of the effect.

CONCLUSION:

Our results suggested that the increased availability of oxygen can, to some extent, improve memory performance.

SIGNIFICANT:

Our findings may improve our understanding of the role of HBO in clinical and practical applications.

KEYWORDS:

Hyperbaric oxygen (HBO); Memory; Regional homogeneity (ReHo); Spatial working memory; Spontaneous activity

PMID:
25703942
DOI:
10.1016/j.clinph.2015.01.010
[Indexed for MEDLINE]

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