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Curr Opin Cell Biol. 2015 Apr;33:119-24. doi: 10.1016/j.ceb.2015.02.002. Epub 2015 Feb 20.

The life cycle of lipid droplets.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, United States.
2
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, United States. Electronic address: Joel.Goodman@UTSouthwestern.edu.

Abstract

Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and recent activity has confirmed that these bona fide organelles are central not only for lipid storage and metabolism, but for development, immunity, and pathogenesis by several microbes. There has been a burst of recent activity on the assembly, maintenance and turnover of lipid droplets that reveals fresh insights. This review summarizes several novel findings in initiation of lipid droplet assembly, protein targeting, droplet fusion, and turnover of droplets through lipophagy.

PMID:
25703629
PMCID:
PMC4380764
DOI:
10.1016/j.ceb.2015.02.002
[Indexed for MEDLINE]
Free PMC Article

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