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Cell. 2015 Feb 26;160(5):829-841. doi: 10.1016/j.cell.2015.01.033. Epub 2015 Feb 19.

Sensory detection of food rapidly modulates arcuate feeding circuits.

Author information

1
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
2
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: zachary.knight@ucsf.edu.

Abstract

Hunger is controlled by specialized neural circuits that translate homeostatic needs into motivated behaviors. These circuits are under chronic control by circulating signals of nutritional state, but their rapid dynamics on the timescale of behavior remain unknown. Here, we report optical recording of the natural activity of two key cell types that control food intake, AgRP and POMC neurons, in awake behaving mice. We find unexpectedly that the sensory detection of food is sufficient to rapidly reverse the activation state of these neurons induced by energy deficit. This rapid regulation is cell-type specific, modulated by food palatability and nutritional state, and occurs before any food is consumed. These data reveal that AgRP and POMC neurons receive real-time information about the availability of food in the external world, suggesting a primary role for these neurons in controlling appetitive behaviors such as foraging that promote the discovery of food.

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PMID:
25703096
PMCID:
PMC4373539
DOI:
10.1016/j.cell.2015.01.033
[Indexed for MEDLINE]
Free PMC Article

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