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Lancet. 1989 Sep 9;2(8663):591-3.

Effects of UK 69 578: a novel atriopeptidase inhibitor.

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1
Department of Cardiology, Western Infirmary, Glasgow.

Abstract

UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.

PMID:
2570286
[Indexed for MEDLINE]
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