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Muscle Nerve. 2015 Oct;52(4):592-7. doi: 10.1002/mus.24611. Epub 2015 Jul 24.

Electrical impedance myography in Duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity.

Author information

1
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, Missouri, 63110, USA.
2
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
3
Skulpt, Inc, Boston, Massachusetts, USA.
4
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
5
Department of Pediatrics and Neurology, University of Colorado, Denver, Colorado, USA.
6
Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
7
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
8
DART Therapeutics, Inc, Stockbridge, Massachusetts, USA.
9
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Abstract

INTRODUCTION:

Electrical impedance myography (EIM) is a non-invasive, painless, objective technique to quantify muscle pathology.

METHODS:

We measured EIM in 8 arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 healthy boys, ages 3-12 years, at 5 centers. We determined the reliability of EIM and compared results in boys with DMD to controls and to 6-minute walk distance (6MWD), North Star Ambulatory Assessment (NSAA), timed functional tests (TFTs), and strength (hand-held dynamometry).

RESULTS:

EIM was well tolerated and had good inter- and intrarater reliability (intraclass correlation coefficient 0.81-0.96). The averaged EIM phase value from all muscles was higher (P < 0.001) in controls (10.45 ± 2.29) than boys with DMD (7.31 ± 2.23), and correlated (P ≤ 0.001) with 6MWD (r = 0.55), NSAA (r = 0.66), TFTs (r = -0.56), and strength (r = 0.44).

CONCLUSION:

EIM is a reliable and valid measure of disease severity in DMD. Longitudinal studies comparing EIM with other assessments over time in DMD are warranted.

KEYWORDS:

Duchenne muscular dystrophy; biomarker; children; electrical impedance myography; myopathy

PMID:
25702806
DOI:
10.1002/mus.24611
[Indexed for MEDLINE]

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