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J Neurol. 2015 Mar;262(3):783-8. doi: 10.1007/s00415-015-7682-y. Epub 2015 Feb 21.

Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.

Author information

1
Behavioural Neurology and Movement Disorders, Mayo Clinic, Rochester, MN, 55905, USA, josephs.keith@mayo.edu.

Abstract

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that both are associated with tau. Recent advances over the past 3 years that are notable to the field are discussed in this review that covers clinical diagnosis, pathological features, neuroimaging and CSF biomarkers, genetic associations and clinical trials related to progressive supranuclear palsy and corticobasal degeneration.

PMID:
25701010
PMCID:
PMC4372246
DOI:
10.1007/s00415-015-7682-y
[Indexed for MEDLINE]
Free PMC Article

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