Format

Send to

Choose Destination
Mol Cell. 2015 Feb 19;57(4):577-581. doi: 10.1016/j.molcel.2015.02.004.

TOPping off meiosis.

Author information

1
Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02454, USA. Electronic address: haber@brandeis.edu.

Erratum in

Abstract

Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers in this issue of Molecular Cell (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these proteins in budding yeast: Sgs1 (BLM homolog), Top3 (TOPIIIα homolog), and Rmi1. They demonstrate several steps where all three proteins act together, and find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meiosis.

PMID:
25699706
PMCID:
PMC4352088
DOI:
10.1016/j.molcel.2015.02.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center