The objective of this article was to explore the effect of correction orbital hypertelorism using inverted U-shaped osteotomy by combined intracranial-extracranial approach. Eleven cases of severe orbital hypertelorism were performed. The measurement of interorbital and intercanthal distance was studied preoperatively and postoperatively by 3-dimensional computed tomography. The interorbital distance of the 11 patients are significantly decreased .The intercanthal distance decreased from 6.7 and 4.8 cm to 5.0 and 3.8 cm, respectively. The inverted U-shaped osteotomy technique may be an effective and safe technique for the stability of the corrected orbital framework and the prevention of recurrence in severe cases of orbital hypertelorism. Moreover, this method has little trauma compared with box osteotomy technique.