Bioactive glycosides from the African medicinal plant Boerhavia erecta L

Nat Prod Res. 2015;29(20):1954-8. doi: 10.1080/14786419.2015.1013470. Epub 2015 Feb 20.

Abstract

Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an unreported glycoside 4, 2,3-dihydroxypropylbenzoate-3-O-β-[4″-methoxy] glucuronide as well as seven known glycosides (1-3, 5-8). The major isolate 5 and 8 indicated a significant inhibition against HIV integrase (IC50 10 and 22 μg/mL, respectively). The extracts and isolates were also tested for anti-malarial activity, but insignificant activity was observed.

Keywords: African medicinal plant; Boerhavia erecta; anti-HIV integrase activity; anti-malarial activity; glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / chemistry*
  • Antimalarials / isolation & purification
  • Burkina Faso
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • HIV Integrase Inhibitors / chemistry*
  • HIV Integrase Inhibitors / isolation & purification
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nyctaginaceae / chemistry*
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plants, Medicinal / chemistry
  • Plasmodium falciparum / drug effects

Substances

  • Antimalarials
  • Glycosides
  • HIV Integrase Inhibitors
  • Plant Extracts