Format

Send to

Choose Destination
J Neurosci. 2015 Feb 18;35(7):3022-33. doi: 10.1523/JNEUROSCI.3028-14.2015.

Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission.

Author information

1
INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France.
2
INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France, Centre National de la Recherche Scientifique, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Unité Mixte de Recherche 5287, 33076 Bordeaux, France, Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, 33076 Bordeaux, France.
3
Centre National de la Recherche Scientifique, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Unité Mixte de Recherche 5287, 33076 Bordeaux, France, Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, 33076 Bordeaux, France.
4
Institut National de la Santé et de la Recherche Médicale, U862 NeuroCentre Magendie, Planar Polarity and Plasticity Group, Bordeaux, France, and University of Bordeaux, U862 NeuroCentre Magendie, Bordeaux, France.
5
INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286, Bordeaux, France, guillaume.ferreira@bordeaux.inra.fr agnes.nadjar@u-bordeaux.fr.

Abstract

The cerebral innate immune system is able to modulate brain functioning and cognitive processes. During activation of the cerebral innate immune system, inflammatory factors produced by microglia, such as cytokines and adenosine triphosphate (ATP), have been directly linked to modulation of glutamatergic system on one hand and learning and memory functions on the other hand. However, the cellular mechanisms by which microglial activation modulates cognitive processes are still unclear. Here, we used taste memory tasks, highly dependent on glutamatergic transmission in the insular cortex, to investigate the behavioral and cellular impacts of an inflammation restricted to this cortical area in rats. We first show that intrainsular infusion of the endotoxin lipopolysaccharide induces a local inflammation and increases glutamatergic AMPA, but not NMDA, receptor expression at the synaptic level. This cortical inflammation also enhances associative, but not incidental, taste memory through increase of glutamatergic AMPA receptor trafficking. Moreover, we demonstrate that ATP, but not proinflammatory cytokines, is responsible for inflammation-induced enhancement of both associative taste memory and AMPA receptor expression in insular cortex. In conclusion, we propose that inflammation restricted to the insular cortex enhances associative taste memory through a purinergic-dependent increase of glutamatergic AMPA receptor expression at the synapse.

KEYWORDS:

AMPA; ATP; cytokines; lipopolysaccharide; neuroinflammation

PMID:
25698740
PMCID:
PMC6605594
DOI:
10.1523/JNEUROSCI.3028-14.2015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center