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Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2729-33. doi: 10.1073/pnas.1418718112. Epub 2015 Feb 18.

Structure of a left-handed DNA G-quadruplex.

Author information

1
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and.
2
Laboratoire de Biochimie, UMR 7654, CNRS, Ecole Polytechnique, Palaiseau 91128, France.
3
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and phantuan@ntu.edu.sg.

Abstract

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

KEYWORDS:

G-quadruplex; NMR; X-ray crystallography; left-handed helix; nucleic acid

PMID:
25695967
PMCID:
PMC4352798
DOI:
10.1073/pnas.1418718112
[Indexed for MEDLINE]
Free PMC Article

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