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J Neurophysiol. 2015 Nov;114(5):2551-4. doi: 10.1152/jn.00948.2014. Epub 2015 Feb 18.

Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans.

Author information

1
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania jjs149@pitt.edu.
2
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.

Abstract

Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their findings stress that atypical activity in the efferent auditory pathway may represent a shared substrate, as well as a potential therapeutic target, in tinnitus and hyperacusis.

KEYWORDS:

efferent; hyperacusis; medial olivocochlear; tinnitus

PMID:
25695650
PMCID:
PMC4630185
DOI:
10.1152/jn.00948.2014
[Indexed for MEDLINE]
Free PMC Article

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