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Neuron. 2015 Feb 18;85(4):683-94. doi: 10.1016/j.neuron.2014.12.060.

The outer subventricular zone and primate-specific cortical complexification.

Author information

1
Stem Cell and Brain Research Institute, INSERM U846, 18 Avenue Doyen Lepine, 69500 Bron, France; Université de Lyon, Université Lyon I, 69003, Lyon, France. Electronic address: colette.dehay@inserm.fr.
2
Stem Cell and Brain Research Institute, INSERM U846, 18 Avenue Doyen Lepine, 69500 Bron, France; Université de Lyon, Université Lyon I, 69003, Lyon, France. Electronic address: henry.kennedy@inserm.fr.
3
Neuroscience Research Institute and Dept Cellular Molecular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address: kenneth.kosik@lifesci.ucsb.edu.

Abstract

Evolutionary expansion and complexification of the primate cerebral cortex are largely linked to the emergence of the outer subventricular zone (OSVZ), a uniquely structured germinal zone that generates the expanded primate supragranular layers. The primate OSVZ departs from rodent germinal zones in that it includes a higher diversity of precursor types, inter-related in bidirectional non-hierarchical lineages. In addition, primate-specific regulatory mechanisms are operating in primate cortical precursors via the occurrence of novel miRNAs. Here, we propose that the origin and evolutionary importance of the OSVZ is related to genetic changes in multiple regulatory loops and that cell-cycle regulation is a favored target for evolutionary adaptation of the cortex.

PMID:
25695268
DOI:
10.1016/j.neuron.2014.12.060
[Indexed for MEDLINE]
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