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Nutr Metab Cardiovasc Dis. 2015 Apr;25(4):382-7. doi: 10.1016/j.numecd.2015.01.001. Epub 2015 Jan 22.

Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity.

Author information

1
Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
2
Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid, Spain; Department of Molecular Medicine, University of Padova, Viale G, Colombo 3, 35121 Padova, Italy. Electronic address: francesco.visioli@unipd.it.

Abstract

BACKGROUND AND AIM:

Obesity is a multi-factorial disorder which is of worldwide concern. In addition to calorie control, some specific dietary components might help resolving some of the complication of obesity, by providing antioxidant and anti-inflammatory activities. We investigated the effect of argan oil supplementation on plasma lipid profile and oxidant-antioxidant status of rats with high-fat diet (HFD)-induced obesity compared with rats fed a normal diet (ND).

METHODS AND RESULTS:

We used an animal model of high fat diet-induced obesity to study the metabolic effects of argan oil and we measured several markers lipid and redox statuses. Consumption of a high-fat diet led to an increase in serum total cholesterol (TC), LDL-cholesterol (LDL-C), and triacylglycerols (TAG) concentrations; however, argan oil blunted the increases of TC, LDL-C and TG, glucose, and insulin. Plasma total antioxidant capacity, erythrocyte catalase and superoxide dismutase activities were lower, whereas plasma hydroperoxide, thiobarbituric acid-reacting substances, and susceptibility of LDL to copper-induced oxidation were higher in obese rats compared with normal rats. Administration of argan oil ameliorated all these indices of redox status.

CONCLUSIONS:

Proper diet and lifestyle should be foremost implemented to reduce the lipoprotein metabolism and oxidant/antioxidant status alterations brought about by obesity. In addition, argan oil reduces the metabolic effects of obesity and its use might be promoted within the context of a balanced diet.

KEYWORDS:

Argan oil; High-fat diet; Insulin; Leptin; Obesity; Oxidant/antioxidant status

PMID:
25694362
DOI:
10.1016/j.numecd.2015.01.001
[Indexed for MEDLINE]

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