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Contemp Oncol (Pozn). 2015;19(1A):A68-77. doi: 10.5114/wo.2014.47136.

The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge.

Author information

1
Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, The Greater Poland Cancer Centre, Poznan, Poland.
2
Laboratory of Gene Therapy, Department of Cancer Immunology, The Greater Poland Cancer Centre, Poznan, Poland ; Department of Cancer Immunology and Diagnostics, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.

Abstract

The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and discover major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. So far, TCGA researchers have analysed large cohorts of over 30 human tumours through large-scale genome sequencing and integrated multi-dimensional analyses. Studies of individual cancer types, as well as comprehensive pan-cancer analyses have extended current knowledge of tumorigenesis. A major goal of the project was to provide publicly available datasets to help improve diagnostic methods, treatment standards, and finally to prevent cancer. This review discusses the current status of TCGA Research Network structure, purpose, and achievements.

KEYWORDS:

The Cancer Genome Atlas (TCGA); big data analysis; cancer genomics

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