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Cardiovasc Res. 2015 Apr 1;106(1):9-18. doi: 10.1093/cvr/cvv049. Epub 2015 Feb 17.

Microengineering in cardiovascular research: new developments and translational applications.

Author information

1
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
2
Center for Engineering in Medicine and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, USA.
3
Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
4
Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore mdccld@nus.edu.sg.

Abstract

Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and disease. In recent years, advances in technical fabrication and biological integration have provided new insights into biological phenomena, improved diagnostic measurements, and made major steps towards de novo tissue creation. Here we review applications of these technologies specific to the cardiovascular field, emphasizing three general categories of use: reductionist vascular models, tissue-engineered vascular models, and point-of-care diagnostics. With continued progress in the ability to purposefully control microscale environments, the detailed study of both primary and cultured cells may find new relevance in the general cardiovascular research community.

KEYWORDS:

Microengineering; microfluidics; point-of-care diagnostics; three-dimensional cell culture; vascular models

PMID:
25691539
PMCID:
PMC4362405
DOI:
10.1093/cvr/cvv049
[Indexed for MEDLINE]
Free PMC Article

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