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BJOG. 2015 Sep;122(10):1377-85. doi: 10.1111/1471-0528.13299. Epub 2015 Feb 18.

Perinatal outcomes following an earlier post-term labour induction policy: a historical cohort study.

Author information

1
Department of Gynaecology, Rigshospitalet, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
2
Department of Obstetrics, Rigshospitalet, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE:

To assess the changes in perinatal outcomes in children born from 37 weeks of gestation after implementation of a more proactive labour induction practice from 2009.

DESIGN:

Register-based cohort study.

SETTING:

Denmark, 2000-12.

POPULATION:

Newborns from 37 weeks of gestation.

METHODS:

Perinatal outcomes were estimated using a logistic regression analysis with adjustment for gestational age, maternal age, parity, plurality, smoking and body mass index.

MAIN OUTCOME MEASURES:

Perinatal outcomes.

RESULTS:

A total of 770 926 infants were included. Labour induction from 37 weeks increased from 9.7% in 2000-02 to 22.5% in 2011-12. From 2003-05 to 2011-12, the risk of umbilical cord pH < 7.0 decreased by 23%; odds ratio (OR) 0.77 (95% confidence interval 0.67-0.89), and the adjusted OR of Apgar score < 7 at 5 minutes was unchanged. The risk of admission to neonatal intensive care units increased by 56%; OR 1.56 (1.47-1.66), whereas the risk of neonatal deaths decreased by 44%; OR 0.56 (0.45-0.70). The risk of cerebral palsy was from 2000-02 to 2009-10 reduced by 26%; OR 0.74 (0.60-0.90). The proportion of infants born with fetal weight ≥ 4500 g decreased by one-third; OR 0.68 (0.65-0.71). However, the risk of shoulder dystocia increased by 32%; OR 1.32 (1.21-1.44), whereas the risk of peripheral nerve injuries was reduced by 43%; OR 0.57 (0.45-0.73).

CONCLUSION:

The results suggest an overall improvement in perinatal outcomes as a result of a more proactive post-term labour induction practice.

KEYWORDS:

Asphyxia; birth induction; misoprostol; perinatal outcome; post-term labour

PMID:
25690911
DOI:
10.1111/1471-0528.13299
[Indexed for MEDLINE]
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