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Mar Drugs. 2015 Feb 16;13(2):1051-67. doi: 10.3390/md13021051.

Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells.

Author information

1
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. ijdae@kangwon.ac.kr.
2
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. lsr1113@inje.ac.kr.
3
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. noddle1@hanmail.net.
4
Department of Life Science, Gachon University, Seongnam 461-701, Korea. white7068@daum.net.
5
Department of Life Science, Gachon University, Seongnam 461-701, Korea. sckang73@gachon.ac.kr.
6
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea. dewykoo@gmail.com.
7
Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea. essohn@kisti.re.kr.
8
The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea. jpbak77@gmail.com.
9
Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea. seungnk@kangwon.ac.kr.
10
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. estrus74@gmail.com.
11
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. microvirus@hanmail.net.
12
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. phykimnr@inje.ac.kr.
13
Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. ehson@kangwon.ac.kr.
14
College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. phyhanj@inje.ac.kr.

Abstract

Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions.

PMID:
25690093
PMCID:
PMC4344618
DOI:
10.3390/md13021051
[Indexed for MEDLINE]
Free PMC Article

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