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Transpl Infect Dis. 2015 Jun;17(3):463-6. doi: 10.1111/tid.12371. Epub 2015 May 19.

A rare case of Cryptococcus gattii pneumonia in a renal transplant patient.

Author information

1
Renal Transplantation, Hospital de Alta Complejidad Pte JD Perón, Formosa, Argentina.
2
Foundation for Research and Assistance in Kidney Disease - FINAER, Buenos Aires, Argentina.

Abstract

Cryptococcus neoformans and Cryptococcus gattii are environmental fungi that can cause fever, cough, pneumonia, meningoencephalitis, dissemination, and death. C. gattii causes cryptococcomas more frequently than does C. neoformans and may require prolonged antifungal treatment. We present a rare case of C. gattii pneumonia in a renal transplant patient. A 44-year-old man, living in a rural area endemic for C. gattii and who had received a kidney transplant, was admitted to the hospital with fever, vomiting, weight loss, and diarrhea. A chest computed tomography revealed 2 alveolar, nodular, subpleural infiltrates in the periphery of the lungs. Differential diagnoses included infectious infiltrates, granulomatosis, embolization, and hemorrhage. C. gattii, molecular type VGI, was confirmed on day 28. Treatment consisted of amphotericin B at 1 mg/kg/day or fluconazole at 800 mg/day for first 6 weeks, followed by fluconazole at 400 mg/day for the subsequent 12 months. Response to the therapy has been slow. Because of the occurrence of outbreaks and its high morbidity and mortality rates, physicians must be aware of this complication in transplant recipients to avoid delays in diagnosis and to provide prompt management.

KEYWORDS:

Cryptococcus gattii; cryptococcosis; kidney transplantation; mycosis; pneumonia

PMID:
25689604
DOI:
10.1111/tid.12371
[Indexed for MEDLINE]

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