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J Nat Prod. 2015 Mar 27;78(3):363-7. doi: 10.1021/np5007586. Epub 2015 Feb 17.

Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015.

Author information

1
†Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
2
‡National Research Laboratory for Cell Physiology and Department of Physiology, Seoul National University College of Medicine, 28 Yonkeun-Dong, Chongno-Ku, Seoul 110-799, Korea.
3
§College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea.
4
⊥Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea.
5
∥Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea.

Abstract

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

PMID:
25689430
DOI:
10.1021/np5007586
[Indexed for MEDLINE]

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