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Nat Chem Biol. 2015 Mar;11(3):182-8. doi: 10.1038/nchembio.1754. Epub 2015 Feb 17.

Collective antibiotic tolerance: mechanisms, dynamics and intervention.

Author information

1
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
2
1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Systems Biology, Duke University, Durham, North Carolina, USA. [3] Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, USA.

Abstract

Bacteria have developed resistance against every antibiotic at a rate that is alarming considering the timescale at which new antibiotics are developed. Thus, there is a critical need to use antibiotics more effectively, extend the shelf life of existing antibiotics and minimize their side effects. This requires understanding the mechanisms underlying bacterial drug responses. Past studies have focused on survival in the presence of antibiotics by individual cells, as genetic mutants or persisters. Also important, however, is the fact that a population of bacterial cells can collectively survive antibiotic treatments lethal to individual cells. This tolerance can arise by diverse mechanisms, including resistance-conferring enzyme production, titration-mediated bistable growth inhibition, swarming and interpopulation interactions. These strategies can enable rapid population recovery after antibiotic treatment and provide a time window during which otherwise susceptible bacteria can acquire inheritable genetic resistance. Here, we emphasize the potential for targeting collective antibiotic tolerance behaviors as an antibacterial treatment strategy.

PMID:
25689336
PMCID:
PMC4806783
DOI:
10.1038/nchembio.1754
[Indexed for MEDLINE]
Free PMC Article

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