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Exerc Sport Sci Rev. 2015 Apr;43(2):75-83. doi: 10.1249/JES.0000000000000043.

Skeletal muscle fatigue and decreased efficiency: two sides of the same coin?

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1 Exercise Physiology Laboratory, Department of Medical and Biological Sciences, University of Udine, Udine, Italy; 2 Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA; and 3 Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Kraków, Poland.


During high-intensity submaximal exercise, muscle fatigue and decreased efficiency are intertwined closely, and each contributes to exercise intolerance. Fatigue and muscle inefficiency share common mechanisms, for example, decreased "metabolic stability," muscle metabolite accumulation, decreased free energy of adenosine triphosphate breakdown, limited O2 or substrate availability, increased glycolysis, pH disturbance, increased muscle temperature, reactive oxygen species production, and altered motor unit recruitment patterns.

[Indexed for MEDLINE]

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