Format

Send to

Choose Destination
J Thorac Cardiovasc Surg. 2015 Apr;149(4):991-6. doi: 10.1016/j.jtcvs.2015.01.019. Epub 2015 Jan 13.

Diffusion-weighted magnetic resonance imaging in preoperative assessment of non-small cell lung cancer.

Author information

1
Department of Thoracic Surgery, Kameda Medical Center, Chiba, Japan. Electronic address: hnomori@qk9.so-net.ne.jp.
2
Department of Thoracic Surgery, Kameda Medical Center, Chiba, Japan.
3
Department of Diagnostic Radiology, Kameda Medical Center, Chiba, Japan.

Abstract

BACKGROUND:

Diffusion-weighted magnetic resonance imaging (DWI) frequently shows heterogeneity of signal intensity (SI) in non-small cell lung cancer (NSCLC). The purpose of our study was to examine the association of SI and DWI patterns with histology, tumor invasiveness, lymph node metastasis, and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in NSCLC.

METHODS:

One hundred forty-five patients with NSCLC underwent preoperative DWI and FDG-PET. DWI patterns were visually classified as homogenous (HOM) (n = 81) or heterogeneous (HET) (n = 64). The former was further classified as faint (faint-HOM) (n = 27) or dark (dark-HOM) (n = 54) according to a cutoff value of SI. Associations of SI and DWI patterns with tumor histology, lymphatic or vascular invasion, pleural invasion, lymph node metastasis, and FDG uptake were evaluated.

RESULTS:

All faint-HOM tumors were well-differentiated adenocarcinoma, whereas dark-HOM and HET tumors were less-differentiated adenocarcinoma or non adenocarcinoma. Although the dark areas in HET tumors showed a dense aggregation of tumor cells, their faint areas showed abundant fibrovascular stroma or necrosis, or a well-differentiated part of adenocarcinoma. Tumor size and the frequencies of lymphatic or vascular invasion, pleural invasion, and nodal metastasis were highest in HET tumors, followed by dark-HOM and faint-HOM (P = .1-P < .001) tumors. Sixty-five tumors having at least 1 of the invasions or metastasis showed significantly higher SI than the 81 tumors without (P < .001). HET tumors had the highest FDG uptake, followed by dark-HOM and faint-HOM tumors; differences between the groups were significant (P < .01 to P < .001).

CONCLUSIONS:

The SI and heterogeneity of DWI reflect the histologic heterogeneity, tumor aggressiveness, and FDG-PET uptake in NSCLC.

KEYWORDS:

Diffusion-weighted imaging; fluorodeoxyglucose; heterogeneity; lung cancer; magnetic resonance imaging; positron emission tomography

PMID:
25686657
DOI:
10.1016/j.jtcvs.2015.01.019
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center