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Biomed Res Int. 2015;2015:730139. doi: 10.1155/2015/730139. Epub 2015 Jan 1.

Fibroblast growth factors stimulate hair growth through β-catenin and Shh expression in C57BL/6 mice.

Author information

1
Department of Nurse, The first Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China.
2
Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
3
School of Nurse, Wenzhou Medical University, Wenzhou 325035, China.
4
Department of Pediatrics, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.
5
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing 100853, China.
6
Department of General Surgery, Cixi People's Hospital, Wenzhou Medical University, Ningbo, China.

Abstract

Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth. The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action. We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice. Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group. Moreover, the immunohistochemical analysis reveals earlier induction of β-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.

PMID:
25685806
PMCID:
PMC4313060
DOI:
10.1155/2015/730139
[Indexed for MEDLINE]
Free PMC Article

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