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Lancet. 1989 Jul 22;2(8656):187-9.

Effect of a Campylobacter pylori protein on acid secretion by parietal cells.

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Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts.


The uptake of [14C]-aminopyrine by rabbit gastric epithelial cells was used as an indirect assay for acid secretion from parietal cells. Campylobacter pylori strains, isolated from the stomachs of 3 patients with chronic gastritis, duodenal ulcer, and near-normal mucosa, respectively, inhibited acid secretion as effectively as 10(-4) mol/l cimetidine. The inhibition occurred with whole organisms and with sonicates. Preliminary characterisation suggested that the inhibition was due to a nondialysable protein. The inhibitor was not toxic to gastric epithelial cells. This bacterial product may explain the hypochlorhydria seen in man acutely infected with C pylori.

[Indexed for MEDLINE]

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