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Pediatr Blood Cancer. 2015 May;62(5):912-4. doi: 10.1002/pbc.25447. Epub 2015 Feb 14.

Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.

Author information

1
Hematology/Oncology, University of California San Francisco Benioff Children's Hospital, Oakland, California.

Abstract

Carbon monoxide (CO) production from heme catabolism is increased with hemolysis. A portable end-tidal CO (ETCO) monitor was used to analyze breath samples in 16 children with sickle cell anemia (SCA, 5-14 years). Median (range) ETCO for SCA was 4.35 ppm (1.8-9.7) versus 0.80 ppm (0.2-2.3) for controls (P < 0.001). ETCOc >2.1 ppm provided sensitivity and specificity of 93.8% (69.8-99.8%) for detecting SCA. ETCO correlated with reticulocytosis (P = 0.015) and bilirubin (P = 0.009), and was 32% lower in children receiving hydroxyurea (P = 0.09). Point-of-care ETCO analysis may prove useful for non-invasive monitoring of hemolysis and as a screening test for SCA.

KEYWORDS:

hemoglobinopathies; red blood cell disorders; sickle cell anemia

PMID:
25683629
PMCID:
PMC4376621
DOI:
10.1002/pbc.25447
[Indexed for MEDLINE]
Free PMC Article

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