Format

Send to

Choose Destination
Respir Med. 2015 Mar;109(3):357-63. doi: 10.1016/j.rmed.2015.01.013. Epub 2015 Feb 3.

Eradication of respiratory tract MRSA at a large adult cystic fibrosis centre.

Author information

1
Adult Cystic Fibrosis Centre, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
2
Dept of Microbiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
3
Adult Cystic Fibrosis Centre, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK.
4
Adult Cystic Fibrosis Centre, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK. Electronic address: n.simmonds@imperial.ac.uk.

Abstract

INTRODUCTION:

The prevalence of MRSA in patients with CF is increasing. There is no consensus as to the optimum treatment.

METHOD:

An observational cohort study of all patients with MRSA positive sputum, 2007-2012. All eradication attempts with subsequent culture results were reviewed. Single vs dual antibiotic regimens were compared for both new and chronic infections.

RESULTS:

37 patients (median FEV1 58.7 (27.6-111.5)% predicted) were identified, of which 67.6% (n = 25) had newly acquired MRSA. Compared with single regimens, a high proportion of dual regimens achieved MRSA eradication (84.6% vs 50%; p = 0.1) for new infections. Rifampicin/Fusidic acid was associated with high success rates (100% vs 60% for other dual regimens (p = 0.13)). Compared with new infections, chronic MRSA was much less likely to be eradicated (18.2%, p = 0.01).

CONCLUSION:

Combined antibiotic therapy, particularly Rifampicin/Fusidic acid, is a well-tolerated and effective means of eradicating MRSA in patients with cystic fibrosis.

KEYWORDS:

Cystic fibrosis; Eradication; Infection; MRSA; Methicillin resistant Staphylococcus aureus

PMID:
25683032
DOI:
10.1016/j.rmed.2015.01.013
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center