Format

Send to

Choose Destination
See comment in PubMed Commons below
Lancet Respir Med. 2015 Apr;3(4):310-8. doi: 10.1016/S2213-2600(15)00043-0. Epub 2015 Feb 12.

Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study.

Author information

1
Center for Investigation and Research in Sleep, University Hospital of Lausanne, Lausanne, Switzerland; Pulmonary Department, University Hospital of Lausanne, Lausanne, Switzerland. Electronic address: raphael.heinzer@chuv.ch.
2
Center for Investigation and Research in Sleep, University Hospital of Lausanne, Lausanne, Switzerland; Pulmonary Medicine Department, University Hospital of Montreal, Montreal, QC, Canada.
3
Department of Internal Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
4
Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
5
Center for Investigation and Research in Sleep, University Hospital of Lausanne, Lausanne, Switzerland.
6
Laboratory Department, University Hospital of Lausanne, Lausanne, Switzerland.
7
Psychiatry Department, University Hospital of Lausanne, Lausanne, Switzerland.
8
University of Southern California San Diego, Division of Pulmonary and Critical Care, La Jolla, CA, USA.
9
Center for Investigation and Research in Sleep, University Hospital of Lausanne, Lausanne, Switzerland; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

Abstract

BACKGROUND:

Sleep-disordered breathing is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for sleep-disordered breathing or cardiovascular diseases. Taking into account improvements in recording techniques and new criteria used to define respiratory events, we aimed to assess the prevalence of sleep-disordered breathing and associated clinical features in a large population-based sample.

METHODS:

Between Sept 1, 2009, and June 30, 2013, we did a population-based study (HypnoLaus) in Lausanne, Switzerland. We invited a cohort of 3043 consecutive participants of the CoLaus/PsyCoLaus study to take part. Polysomnography data from 2121 people were included in the final analysis. 1024 (48%) participants were men, with a median age of 57 years (IQR 49-68, range 40-85) and mean body-mass index (BMI) of 25·6 kg/m(2) (SD 4·1). Participants underwent complete polysomnographic recordings at home and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression. The primary outcome was prevalence of sleep-disordered breathing, assessed by the apnoea-hypopnoea index.

FINDINGS:

The median apnoea-hypopnoea index was 6·9 events per h (IQR 2·7-14·1) in women and 14·9 per h (7·2-27·1) in men. The prevalence of moderate-to-severe sleep-disordered breathing (≥15 events per h) was 23·4% (95% CI 20·9-26·0) in women and 49·7% (46·6-52·8) in men. After multivariable adjustment, the upper quartile for the apnoea-hypopnoea index (>20·6 events per h) was associated independently with the presence of hypertension (odds ratio 1·60, 95% CI 1·14-2·26; p=0·0292 for trend across severity quartiles), diabetes (2·00, 1·05-3·99; p=0·0467), metabolic syndrome (2·80, 1·86-4·29; p<0·0001), and depression (1·92, 1·01-3·64; p=0·0292).

INTERPRETATION:

The high prevalence of sleep-disordered breathing recorded in our population-based sample might be attributable to the increased sensitivity of current recording techniques and scoring criteria. These results suggest that sleep-disordered breathing is highly prevalent, with important public health outcomes, and that the definition of the disorder should be revised.

FUNDING:

Faculty of Biology and Medicine of Lausanne, Lausanne University Hospital, Swiss National Science Foundation, Leenaards Foundation, GlaxoSmithKline, Ligue Pulmonaire Vaudoise.

PMID:
25682233
PMCID:
PMC4404207
DOI:
10.1016/S2213-2600(15)00043-0
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center