Format

Send to

Choose Destination

The role of excitatory amino acids in synaptic transmission in the hippocampus.

Author information

1
Institute of Physiology, Universitetsparken, University of Aarhus, Denmark.

Abstract

We have highlighted some aspects of the action of excitatory amino acid transmission in the hippocampus. Fast epsps can be blocked by CNQX to reveal a component of synaptic transmission which is mediated by NMDA receptors. Extracellular recordings of ionic activities show that NMDA and non-NMDA ionophores are permeable to the major monovalent cations, while NMDA ionophores also appear to be permeable to Ca2+. Interactions of agonists applied by iontophoresis may be correlates of phenomena such as LTP, which can be evoked by appropriate synaptic stimulation.

PMID:
2568222
DOI:
10.1016/0300-9629(89)90207-7
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center