Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors

FEBS Lett. 2015 Mar 12;589(6):766-72. doi: 10.1016/j.febslet.2015.02.006. Epub 2015 Feb 12.

Abstract

Human D-type prostanoid (DP) and E-type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and found that EP2 receptors have 8-fold fewer amino acid mutations. We speculate that EP2 receptors exhibit more constraints to mutations than DP receptors.

Keywords: DP receptor; EP2 receptor; Prostaglandin D(2); Prostaglandin E(2); Prostanoid receptor; Tandem duplication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Mice
  • Mutation
  • Polymorphism, Single Nucleotide
  • Receptors, Immunologic / genetics*
  • Receptors, Prostaglandin / genetics*
  • Receptors, Prostaglandin E, EP2 Subtype / genetics*

Substances

  • PTGER2 protein, human
  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • Receptors, Prostaglandin E, EP2 Subtype
  • prostaglandin D2 receptor