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J Biotechnol. 2015 Apr 10;199:21-2. doi: 10.1016/j.jbiotec.2015.02.004. Epub 2015 Feb 11.

Complete genome sequence of Streptomyces lividans TK24.

Author information

1
Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany.
2
Matís, Vínlandsleið 12, 113 Reykjavík, Iceland.
3
BioXpr SA, B-5000 Namur, Belgium.
4
GlaxoSmithKline, 315 Cambridge Science Park, Cambridge CB4 0WG, UK.
5
Chemical and Biochemical Process Technology and Control Section (BioTeC), Department of Chemical Engineering, KU Leuven, Belgium.
6
Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. Electronic address: jozef.anne@rega.kuleuven.be.
7
Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; Institute of Molecular Biology and Biotechnology-FoRTH and Department of Biology-University of Crete, Iraklio, Crete, Greece. Electronic address: tassos.economou@rega.kuleuven.be.
8
Center for Biotechnology (CeBiTec), Universität Bielefeld, Bielefeld, Germany. Electronic address: joern.kalinowski@cebitec.uni-bielefeld.de.

Abstract

Streptomyces lividans TK24 is the standard host for the heterologous expression of a number of different proteins and antibiotic-synthesizing enzymes. As such, it is often used as an experimental microbial cell factory for the production of secreted heterologous proteins including human cytokines and industrial enzymes, and of several antibiotics. It accepts methylated DNA and is an ideal Streptomyces cloning system. Here, we report the complete genome sequence of S. lividans TK24 that includes a plasmid-less genome of 8.345Mbp (72.24% G+C content).

KEYWORDS:

Genome sequence; Heterologous protein expression; Model organism; Streptomyces

PMID:
25680930
DOI:
10.1016/j.jbiotec.2015.02.004
[Indexed for MEDLINE]

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