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J Neural Transm (Vienna). 2015 Sep;122(9):1319-22. doi: 10.1007/s00702-015-1381-9. Epub 2015 Feb 14.

Elevated fecal calprotectin in patients with Alzheimer's dementia indicates leaky gut.

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Department of Gerontology, Landesnervenklinik Wagner-Jauregg Linz, Wagner-Jauregg Weg 15, 4020, Linz, Austria.


Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer's disease (AD) and compared with serum concentrations of aromatic amino acids. Calprotectin concentrations were mean ± SEM 140 ± 31.9 mg/kg, 16 patients (73%) presented with concentrations outside normal (>50 mg/kg). Concentrations correlated inversely with serum levels of tryptophan, tyrosine and phenylalanine (all p < 0.05). Increased concentrations of fecal calprotectin indicate a disturbed intestinal barrier function in AD patients which could be of relevance for the lowering of essential aromatic amino acids concentrations in the blood.

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