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Diagn Microbiol Infect Dis. 2015 Apr;81(4):264-8. doi: 10.1016/j.diagmicrobio.2015.01.003. Epub 2015 Jan 16.

Clonal distribution of multidrug-resistant Enterobacter cloacae.

Author information

1
INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France.
2
INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
3
INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland; Hopital Fribourgeois-hôpital Cantonal, Fribourg, Switzerland. Electronic address: patrice.nordmann@unifr.ch.

Abstract

A multilocus sequence typing (MLST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various β-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme.

KEYWORDS:

Enterobacter cloacae; MLST; Multidrug-resistant bacteria; Prevalence

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