Solving the centriole disengagement puzzle

Nat Cell Biol. 2015 Jan;17(1):3-5. doi: 10.1038/ncb3087.

Abstract

The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.

Publication types

  • Comment

MeSH terms

  • Antigens / metabolism*
  • Cell Cycle Proteins
  • Centrioles / genetics*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Microtubule-Associated Proteins / genetics*
  • Microtubule-Associated Proteins / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Proteolysis*

Substances

  • Antigens
  • CDK5RAP2 protein, human
  • CEP68 protein, human
  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • pericentrin