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Curr Environ Health Rep. 2014 Sep 7;1(4):341-352.

Zebrafish: A marvel of high-throughput biology for 21st century toxicology.

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Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97333.
Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695.


The evolutionary conservation of genomic, biochemical and developmental features between zebrafish and humans is gradually coming into focus with the end result that the zebrafish embryo model has emerged as a powerful tool for uncovering the effects of environmental exposures on a multitude of biological processes with direct relevance to human health. In this review, we highlight advances in automation, high-throughput (HT) screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in our understanding of how chemicals in our environment affect our health and wellbeing.


Zebrafish embryo model; environmental exposure; high-throughput screening; human health

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