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Int J Womens Health. 2015 Feb 4;7:189-203. doi: 10.2147/IJWH.S52379. eCollection 2015.

New perspectives on targeted therapy in ovarian cancer.

Author information

1
Mater Health Services, Raymond Terrace, South Brisbane, QLD, Australia ; Inflammtion and Cancer Therapeutics Group, Mater Research, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, QLD, Australia ; School of Medicine, University of Queensland, Brisbane, QLD, Australia.
2
Mater Health Services, Raymond Terrace, South Brisbane, QLD, Australia.

Abstract

Epithelial ovarian cancer remains the most lethal gynecologic malignancy. During the last 15 years, there has been only marginal improvement in 5 year overall survival. These daunting statistics are compounded by the fact that despite all subtypes exhibiting striking heterogeneity, their systemic management remains identical. Although changes to the scheduling and administration of chemotherapy have improved outcomes to a degree, a therapeutic ceiling is being reached with this approach, resulting in a number of trials investigating the efficacy of targeted therapies alongside standard treatment algorithms. Furthermore, there is an urge to develop subtype-specific studies in an attempt to improve outcomes, which currently remain poor. This review summarizes the key studies with antiangiogenic agents, poly(adenosine diphosphate [ADP]-ribose) inhibitors, and epidermal growth factor receptor/human epidermal growth factor receptor family targeting, in addition to folate receptor antagonists and insulin growth factor receptor inhibitors. The efficacy of treatment paradigms used in non-ovarian malignancies for type I tumors is also highlighted, in addition to recent advances in appropriate patient stratification for targeted therapies in epithelial ovarian cancer.

KEYWORDS:

PARP inhibition; antiangiogenic therapy; cancer-related inflammation; high-grade serous; low grade ovarian cancer

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