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Diabetes Care. 2015 May;38(5):934-6. doi: 10.2337/dc14-2348. Epub 2015 Feb 12.

The risk of type 1 diabetes among offspring of immigrant mothers in relation to the duration of residency in Sweden.

Author information

1
Department of Environmental Medicine, Division of Epidemiology, Unit of Cardiovascular Epidemiology, Karolinska Institutet, Stockholm, Sweden.
2
Department of Environmental Medicine, Division of Epidemiology, Unit of Cardiovascular Epidemiology, Karolinska Institutet, Stockholm, Sweden Centre for Epidemiology and Social Medicine, Health Care Services, Stockholm County Council, Stockholm, Sweden.
3
Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden martina.persson@ki.se.

Abstract

OBJECTIVE:

The risk for type 1 diabetes mellitus (T1DM) is increased in the second compared with the first generation of immigrants in Sweden. We investigated the effect of the mother's duration of stay in Sweden on the risk of T1DM in the offspring.

RESEARCH DESIGN AND METHODS:

Using data from national registries, we identified all subjects with T1DM among 984,798 children born in Sweden (aged 0-18 years) between 1992 and 2009. Incidence rate ratios (IRRs) with 95% CI were estimated using Poisson regression.

RESULTS:

Offspring of mothers living in Sweden for up to 5 years had a 22% lower risk of T1DM (adjusted IRR 0.78, 95% CI 0.63-0.96) compared with offspring of mothers living in Sweden for 11 years or more. The risk increased with the mother's duration of stay in Sweden.

CONCLUSIONS:

Our findings support the hypothesis that immigration to Sweden is associated with exposure to new environmental factors that contribute to the development of T1DM in genetically susceptible individuals.

PMID:
25678102
DOI:
10.2337/dc14-2348
[Indexed for MEDLINE]

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