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Aging Cell. 2015 Jun;14(3):491-5. doi: 10.1111/acel.12325. Epub 2015 Feb 9.

Accelerated epigenetic aging in Down syndrome.

Author information

1
Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA; Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Abstract

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)).

KEYWORDS:

DNA methylation; Down syndrome; biomarker of aging; epigenetics

PMID:
25678027
PMCID:
PMC4406678
DOI:
10.1111/acel.12325
[Indexed for MEDLINE]
Free PMC Article

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