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Nat Rev Immunol. 2015 Mar;15(3):185-9. doi: 10.1038/nri3803. Epub 2015 Feb 13.

A brief history of T cell help to B cells.

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  • 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, California 92037, USA.

Abstract

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+) T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.

PMID:
25677493
PMCID:
PMC4414089
DOI:
10.1038/nri3803
[PubMed - indexed for MEDLINE]
Free PMC Article
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