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Clin Infect Dis. 2015 Jun 1;60(11):1690-9. doi: 10.1093/cid/civ095. Epub 2015 Feb 12.

The Burden of Healthcare-Associated Infections in Southeast Asia: A Systematic Literature Review and Meta-analysis.

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Infection Control, Singapore General Hospital, Singapore.
Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand.
Department of Epidemiology and Biostatistics, College of Public Health, University of the Philippines, Manila.


A systematic literature review and meta-analysis of the burden of healthcare-associated infections (HAIs) in Southeast Asia was performed on 41 studies out of the initially identified 14 089 records. The pooled prevalence of overall HAIs was 9.0% (95% confidence interval [CI], 7.2%-10.8%), whereas the pooled incidence density of HAI was 20 cases per 1000 intensive care unit-days. The pooled incidence density of ventilator-associated pneumonia, central line-associated bloodstream infection, and catheter-associated urinary tract infection was 14.7 per 1000 ventilator-days (95% CI, 11.7-17.7), 4.7 per 1000 catheter-days (95% CI, 2.9-6.5), and 8.9 per 1000 catheter-days (95% CI, 6.2-11.7), respectively. The pooled incidence of surgical site infection was 7.8% (95% CI, 6.3%-9.3%). The attributed mortality and excess length of stay in hospitals of infected patients ranged from 7% to 46% and 5 to 21 days, respectively.


Southeast Asia; epidemiology; healthcare-associated infections; meta-analysis; systematic literature review

[Indexed for MEDLINE]

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