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Clin Chest Med. 2015 Mar;36(1):13-34. doi: 10.1016/j.ccm.2014.10.002. Epub 2014 Nov 6.

Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.

Author information

1
Epidemiology Unit, Laboratory of Clinical Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 15B-1, 8 West Drive, MSC 2665, Bethesda, MD 20892, USA. Electronic address: rprevots@niaid.nih.gov.
2
Division of Respirology, Department of Medicine, University of Toronto and Toronto Western Hospital, 399 Bathurst Street, 7E-452, Toronto, ON M5T 2S8, Canada.

Abstract

Population-based data have documented a worldwide increase in the prevalence of human nontuberculous mycobacterial (NTM) infections since 2000. Mycobacterium avium complex is predominant in North America and East Asia, whereas in regions within Europe, M kansasii, M xenopi, and M malmoense are more common. Host factors important to the current epidemiology of NTM pulmonary disease include thoracic skeletal abnormalities, rheumatoid arthritis, and use of immunomodulatory drugs. Clustering of disease within families suggests a heritable genetic predisposition to disease susceptibility. Warm, humid environments with high atmospheric vapor pressure contribute to population risk.

KEYWORDS:

Epidemiology; Global; Nontuberculous mycobacteria; Pulmonary disease

PMID:
25676516
PMCID:
PMC4332564
DOI:
10.1016/j.ccm.2014.10.002
[Indexed for MEDLINE]
Free PMC Article

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